Putting Science to Work

Exploratory/Discovery Toxicology

Syngene has proven experience to carry out a range of toxicology services to provide seamless integration between discovery and development programs.

General Toxicology

Study types include dose escalation studies, tolerability studies, and dose range finding studies.

Standard Species
  • Rat
  • Mouse
  • Rabbit
  • Guinea Pig
Routes of Administration
  • Oral (gavage or dietary)
  • Intravenous
  • Intramuscular
  • Intraperitoneal
  • Subcutaneous
  • Dermal

We specialize in the development of bioanalytical methods to support Bioavailability and Pharmacokinetics studies. We provide both non-GLP and GLP bioanalytical services for both small and large molecules. The services include:

  • HPLC -UV and LC-MS/MS based methods and Elisa technology
  • Development of specialized Elisa Kits to meet project specific needs
  • Development of efficient extraction procedures (protein precipitation, liquid-liquid extraction, solid-phase extraction)
  • Development of analytical methods in the presence of different matrices (plasma, brain, liver, bile etc) and different species.
  • Immunogenicity and Neutralizing Antibody analysis.
  • In vivo Toxicokinetics (Rats & Mice)
  • Dosing of animals
  • Collection and processing of samples
Clinical Chemistry and Histopathology

Syngene has the state-of-the-art facility to provide a broad based analysis of a variety of parameters in each of the following categories:

  • Hematological analysis
  • Clinical chemistry analysis
  • Urinalysis
  • Gross pathology services
  • Histopathology services:
    • Routine and special histochemical staining
    • Immunohistochemistry techniques

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