Putting Science to Work

Data Annotation and Analysis

The Syngene Data Annotation and Analysis teams provide a range of services to aid early discovery, target identification and validation and biomarker discovery. This includes preparation of pharmacogenomic target reports, data analysis of high throughput genomic & proteomic data, pathway annotation & knowledgebase curation, and clinical relevance of NGS data.

Data Analysis and Pathway annotation

High throughput genomic data can be used to derive insights into genes and pathways that are altered either in a disease or upon treatment with a drug or NCE either in vitro or in vivo. This can lead to a better understanding of the biology behind the observed phenotypes, targets that may be valuable, actions of a drug or a drug class and surrogate markers of interest. Our team can analyze these data sets efficiently to provide:

  • An understanding of the significant differential gene expression patterns relative to the condition of interest.
  • An association of the gene expression signature obtained with the most relevant signalling pathways that may be impacted.
  • A review of the published literature for each relation to obtain a precise and succinct pathway annotation that may be represented as curated pathway figures.
Knowledge Base Curation

Our team can create knowledge bases and annotated interaction networks in a specific disease area or organ of interest. These curated pathways can be used to overlay data from experiments, derive therapeutic hypotheses, generate mechanism of action and compare compounds based on their biological effects.

Clinical Relevance of NGS Data

Clinical interpretation of variants identified via NGS is crucial in applying the knowledge obtained from the mutation profile for better health care. Scientists in the bioinformatics team are experienced in interpreting NGS data obtained from sequencing of germline/somatic mutations in several disease areas including genetically defined diseases, cardiac disorders and cancer.

The Syngene Data Annotation and Analysis teams provide a range of services to aid early discovery, target identification and validation and biomarker discovery. This includes preparation of pharmacogenomic target reports, data analysis of high throughput genomic & proteomic data, pathway annotation & knowledgebase curation, and clinical relevance of NGS data.

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